The primary difference is depth rating and case construction. The standard Sea-Dweller is rated to 1,220 metres (4,000 feet) with a 43mm case that's noticeably robust but still wearable for most people.
The Deepsea is rated to an extreme 3,900 metres (12,800 feet), achieved through the Ringlock System—an internal architecture that allows the crystal and case back to be independently supported by a nitrogen-alloyed steel compression ring. This engineering marvel makes the Deepsea thicker and heavier, with a 44mm diameter. On the wrist, the Deepsea has serious presence—some call it commanding, others call it massive.
If you have a smaller wrist or prefer subtlety, the standard Sea-Dweller is more versatile. If you want maximum wrist presence and the security of knowing your watch can handle pressures that would crush a submarine, choose the Deepsea. Both are exceptional; it's about size preference and how much over-engineering you want.